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In vitro studies have demonstrated that enteric neurons play a role in inhibiting the differentiation of CD4+ CD25+ FOXP3 high Treg (peripherally induced). The factors secreted by these neurons have underscored the importance of interleukin-6 (IL-6) in this process. IL-6 has been identified as a modulator of iTreg cell formation and has an impact on the proportion of RORgamma+ cells. Additionally, colonization with commensal microbes has been observed to reduce colon neuronal density. When IL-6 is conditionally ablated, there is an increase in the total number of [RAR-related Orphan Receptor Gamma/T (ROR-gamma/t) Isoform 2 (NR1F3)t+ Foxp3+…