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ATP nucleosidases are immune effectors which cleave ATP molecules into Adenines and ribose-5′-triphosphate both in vitro and during phage infection in E. coli. In bacteria, the ATP nucleosidase domain acts as a key part of various defense systems, including Cyclic-oligonucleotide-based Anti-phage Signaling System (CBASS) and NLR-like proteins. ATP nucleosidase domain exists in many different eukaryotic organisms. These include fungi, corals,…