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Medical Research Finder

meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

Interleukin-1 (IL-1) beta (IL-1F2) & T helper 17 cell (Th17)

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Interleukin-1 (IL-1) beta (IL-1F2) is also crucial for T helper 17 cell (Th17) differentiation and is specifically induced by the gut microbiota
Shaw et al. 2012 J Exp Med 209(2): 251–8.
Hu et al. 2011a Immunity 35(6): 1010-22

Besides other effects, IL-1 beta induces the expression of the transcription factor IRF4, which is needed for the expression of RAR-related orphan receptor gamma/t (ROR-gamma/t) Isoform 2 (NR1F3) in T helper 17 cell (Th17)
Chung…

Critical regulation of early Th17 cell differentiation by interleukin-1 signaling
Chung et al. 2009 Immunity 30(4): 576-87
Microbiota-induced IL-1β, but not IL-6, is critical for the development of steady-state TH17 cells in the intestine
Shaw et al. 2012 J Exp Med 209(2): 251–8.
Priming microenvironments dictate cytokine requirements for T helper 17 cell lineage commitment
Hu et al. 2011a Immunity 35(6): 1010-22
TH17 cell and epithelial cell crosstalk during inﬂammatory bowel disease and carcinogenesis
Kempski et al. 2017
Review

7/1/2026