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The treatment of advanced Melanoma (cutaneous) with anti-PD-1 antibodies shows long-term clinical benefits. The composition of the gut microbiota correlates with the efficacy of anti-PD-1 in preclinical models and in patients. Can the commonly occurring resistance to anti-PD-1 be overcome by altering the gut microbiota through Fecal Microbiota Transplantation (FMT)? (1)
It is an open label clinical phase II treatment tr…