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Aprepitant demonstrated significant ulcer inhibition effects, with rates of 48.14%, 49.62%, 65.92%, and 76.77% at doses of 5, 10, 20, and 40 mg/kg, respectively. The administration of aprepitant resulted in a dose-dependent decrease in oxidative stress and inflammatory markers in stomach tissues. Notably, COX-2 mRNA levels increased at doses of 20 and 40 mg/kg.
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