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Ribosome biogenesis (RiBi) is one of the most complex and energy demanding processes in human cells, critical for cell growth and proliferation. Strong causal links between inherited and acquired impairment in RiBi with cancer pathogenesis are emerging, pointing to RiBi as an attractive therapeutic target for cancer
Various types of RiBi dysregulation have been linked with alterations in protein synthesis and proteostasis, metabolic processes, redox homeostasis, genome stability, and transcription
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