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Ageing is a process of decline in physiological function and capability over time. It is an anticipated major burden on societal health-care costs due to an increasingly aged global population. Accelerated biological ageing is a feature of age-related morbidities, which also appear to share common underpinning features, including low-grade persistent inflammation, phosphate toxicity, diminished Nrf2 activity, a depleted metabolic capability, depressed mitochondrial biogenesis and a low diversity gut microbiome.
Social, psychological, lifestyle and nutritional risk factors can all influence the trajectory of age-related health , as part of an individual’s exposome, which reflects the interplay between the genome and the environment . This is manifest as allostatic (over)load reflecting the burden of lifestyle/di…