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Cocaine raises gut norepinephrine levels facilitating Proteobacteria colonization. Proteobacteria colonization depletes glycine in gut, blood, and CSF in mice. Glycine depletion alters cocaine-induced neuroplasticity and drug response. Systemic or bacteria-mediated glycine replenishment restores cocaine responses
Convincing evidence now exists for a role of the gut microbiota composition in regulating the stress hormone corticosterone (cortisol in humans)
Schmidt et al. 2015a Psychopharmacology (Berl.) 232(10): 1793-1801
Animal studies have shown that …