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Nuclear factor erythroid 2-related factor 2 (NFE2L2) downregulates certain inflammatory pathways and upregulates various antioxidant enzymes to maintain a balance.
Several Nrf2 Modulators are now in clinical trials and can help reduce oxidative stress and neuroinflammation.
Nrf2 is a crucial transcription factor that goes beyond merely managing antioxidant and detoxification responses. Transcriptomic profiling, sequencing of Nrf2-bound DNA, and Nr…