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Leinamycins contain a unique 1,3-dioxo-1,2-dithiolane moiety spirofused to an 18-membered macrolactam ring. It is a promising anticancer drug lead due to its potent activity and unprecedented mode of action [34].
Kalkreuter et al. 2020 Trends in Pharmacological Sciences 41: 13 (in IM)
Although it was discovered from Streptomyces atroolivaceus S-140 in 1989, no additional natural producers or analogs were reported for almost 30 years [35].
Kalkreuter et al. 2020 Trends in Pharmacological Sciences 41: 13 (in IM)
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