Bacterial Polysaccharide A (PSA) & Bacteroides fragilis

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Production of Bacterial Polysaccharide A (PSA) by Bacteroides fragilis has been proposed to be instrumental for the bacterium’s success as a commensal (9). It is suggested that Bacterial Polysaccharide A (PSA), produced by Bacteroides fragilis, is an identified symbiont factor model for immunomodulation. Thus, PSA could be one of the potentially numerous bacterial cell components capable of promoting protective responses against [neuroinflammation](b…

A bacterial carbohydrate links innate and adaptive responses through Toll-like receptor 2
Wang et al. 2006a J Exp Med. 203: 2853–63.
A polysaccharide from the human commensal Bacteroides fragilis protects against CNS demyelinating disease
Ochoa-Reparaz et al. 2010 Mucosal Immunol. 3: 487-495
IL-2 mediates protection against abscess formation in an experimental model of sepsis
Tzianabos et al. 1999 J Immunol. 163: 893–97.
Interactions between the microbiota and the immune system
Hooper et al. 2012
Plasmacytoid dendritic cells mediate anti-inflammatory responses to a gut commensal molecule via both innate and adaptive mechanisms
Dasgupta et al. 2014 Cell Host and Microbe. 15: 413-423
The yin yang of bacterial polysaccharides: Lessons learned from B. fragilis PSA
Surana & Kasper 2012 Immunol Rev. 245: 13–26
Transmission of the gut microbiota: spreading of health
Browne et al. 2017
Review

11/5/2026