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Niraparib (MK-4827) is a selective inhibitor of PARP1/2 with IC50 of 3.8 nM/2.1 nM, with great activity in cancer cells with mutant BRCA-1 and BRCA-2. It is >330-fold selective against PARP3, V-PARP and Tank1
Niraparib works by inducing synthetic lethality through its targeting of homologous recombination DNA repair. This pathway is often disrupted in ovarian cancer, especially when BRCA mutations are present.
Niraparib is a poly(ADP-ribose) polymerase inhibitor, orally available
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