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sPLA2-IIA is an endogenous antimicrobial protein produced by many tissues and host cells, and displays high constitutive expression at barrier sites and inducible expression in the circulation.
The enzyme type IIA secreted phospholipase A2 (sPLA2-IIA) is crucial for mammalian innate host defense against bacterial pathogens.
sPLA2-IIA is unique in its particular selectivity and potency in killing Gram-positive bacteria;
it plays an underappreciated role in defense against Gram-negative pathogens
sPLA2-IIA could be used as a stand- alone therapeutic agent, or as an adjunct therapy to…