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ABSTRACT
Tumor-associated neutrophils (TANs) play a central role in modulating the tumor microenvironment and the antitumor immune response.
Targeting these cells may offer new treatment options in the context of immune checkpoint inhibitors.
(1) the development of cancer is associated with a profound change in the biogenesis and function of neutrophils with effects on the response to ICIs,
(2) neutrophil infiltration into the tumor is associated with key features of resistance to ICIs,
(3) TANs also play an important role in resistance to antiangiogenic drugs…