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Phthoxazolin A is an oxazole-containing polyketide with anti-oomycete and herbicidal activities.
It was identified as a cryptic metabolite of Streptomyces avermitilis.
It acts as a specific inhibitor of cellulose biosynthesis and exhibits antifungal activity against Phytophthora spp. and potent herbicidal activity
The biosynthetic gene cluster for phthoxazolin A was characterized through genome sequencing, revealing 8 open reading frames responsible for its biosynthesis.
The first total synthesis of phthoxazolin A involved a series of palladium-catalyzed cross-c…