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XusB is a xenosiderophore-binding lipoprotein that is produced by the human gut commensal Bacteroides thetaiotaomicron and related Bacteroidetes. It is enriched in outer membrane vesicles and plays a crucial role as a component of a xenosiderophore-uptake system, enabling these bacteria to acquire iron from siderophores produced by other microbes, which is why it is referred to as "xeno-". XusB delivers the iron‑loaded siderophore to the Ton…