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It is a randomized, double-blind, placebo-controlled clinical trial studying ⩾ 3 × 10^9 CFU per 1.5 g sachet Bifidobacterium longum R0175 + Lactobacillus helveticus R0052 or placebo in 79 analyzed patients for eight weeks (1)
Change Montgomery–Åsberg Depression Rating Scale (1)
The study found no significant differences between the probiotic and placebo groups regarding any psychological outcome measures, with Cohen’s d ranging from 0.07 to 0.16. Similarly, there were no notable differences in any blood-based biomarkers.
At the study's end-point, 9 participants (23%) in the probiotic group exhibited a 60% or greater improvement on the Montgomery–Åsberg Depression Rating Sc…