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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Midazolam

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Midazolam, a benzodiazepine sedative, is a standard CYP3A metabolized drug. It is not a P-glycoprotein substrate.
Togao et al. 2020 Biopharm Drug Dispos 41: 275-82

Midazolam is commonly used to assess Cyp3a activity in mice. However, various studies have indicated that Cyp2c, along with Cyp3a, plays a significant role in the metabolism of midazolam into 1′-OH midazolam in these animals.
Perloff et al. 2000 Journal of Pharmacology and Experimental Therapeutics 292(2): 618-628
Greenblatt et al. 2003 Clinical Pharmacology & Therapeutics 74(2): 121-129
Van Water…

References (Sources)

Contribution of the N-glucuronidation pathway to the overall in vitro metabolic clearance of midazolam in humans
Klieber et al. 2008 Drug Metabolism and Disposition 36(5): 851-862
Effects of gut microbiota on in vivo metabolism and tissue accumulation of cytochrome P450 3A metabolized drug: midazolam
Togao et al. 2020 Biopharm Drug Dispos 41: 275-82
Midazolam and triazolam biotransformation in mouse and human liver microsomes: Relative contribution of CYP3A and CYP2C isoforms
Perloff et al. 2000 Journal of Pharmacology and Experimental Therapeutics 292(2): 618-628
Midazolam metabolism in cytochrome P450 3A knockout mice can be attributed to up-regulated CYP2C enzymes
Van Waterschoot et al. 2008 Molecular Pharmacology 73(3): 1029-1036
Time course of recovery of cytochrome P450 3A function after single doses of grapefruit juice
Greenblatt et al. 2003 Clinical Pharmacology & Therapeutics 74(2): 121-129

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Midazolam - Wikipedia