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Colibactin induces double-strand breaks in cultured cells
Colibactin is a DNA damaging molecule
Colibactin is believed to alkylate DNA on adenine residues. This results in DNA damage, and errors in the repair process lead to mutations
Colibactin or colibactin-producing bacteria are involved in the development of Carcinogenesis / Oncogenesis / Tumorigenesis & Colorectal cancer (CRC)
Pleguezuelos-Manzano et al. 2020 Nat…