Loading…
Please register to continue your trial period!
meRfi Microbiome provides you with up-to-date, evidence-based insights on the gut microbiota and related health topics.
Access our ever-expanding digital library and get personalized answers through our interactive AI chat platform.
Start your free trial and transform your understanding of the gut microbiota today!
Asparaginase is commonly used as a part of a multidrug regimen for acute lymphoblastic leukemia treatment.
Asparaginase (ASNase) is an important component of acute lymphoblastic leukemia (ALL) treatment, but is often discontinued because of toxicity.
Therapeutic drug monitoring (TDM) of asparaginase results in a significant reduction of the PEGasparaginase dose with adequate asparaginase activity levels and sufficient asparagine depletion. Also, with TDM, silent inactivation and allergic-like reactions are identified. However, there is limited effect of reduced asparaginase activity levels on toxici…