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A choline-deficient diet can have profound effects on liver health, primarily through the induction of Non-Alcoholic Fatty Liver Disease (NAFLD) and Non-Alcoholic Steatohepatitis (NASH / MASH), characterized by lipid accumulation, inflammation, and fibrosis.
Animal studies have shown that a methionine-choline-deficient (MCD) diet can rapidly induce liver fibrosis and significantly affect gene expression related to lipid metabolism, inflammation, oxidative stress, and fibrogenesis pathways
Huang…