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Experimental autoimmune encephalomyelitis (EAE) is a T cell mediated inflammatory autoimmune disease of the central nervous system in mice and a model for multiple sclerosis.
In experiments with mice that had autoimmune encephalitis (EAE), after feeding Lactiplantibacillus plantarum A7 and Bifidobacterium animalis PTCC 1631, the transcription factor Foxp3 of naive T cells increased, resulting in increased Treg differentiation and Interleukin-10 (IL-10) Production