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Human-associated Gordonibacter and Eggerthella strains 21-dehydroxylate 3a5a Tetrahydrodeoxycorticosterone (THDOC). The resulting tetrahydro progesterones (progestins) are enriched in the feces of pregnant human donors. Moreover, feces from pregnant subjects are enriched in the cluster-containing bacteria. The gut microbiome and pregnancy state influence progestin levels in the intestine.
Levels of certain bacterial [progestins](brain://kzEHka52yEaF1oC3W…