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Chimeric Antigen Receptor Macrophages (CAR-M) involve engineering macrophages to express chimeric antigen receptors (CARs).
Upon binding, Chimeric Antigen Receptor Macrophages (CAR-M) engineered macrophages can initiate the phagocytosis of cancer cells, effectively engulfing and destroying them.
This process directly reduces tumor mass and potentially alters the tumor microenvironment (TME) to a more immunogenic state.
Unlike T cells, macrophages can naturally infiltrate solid tumors and…