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Fructose consumption is with the increasing incidence of obesity and cancer.
Obesity and cancer are the leading causes of morbidity and mortality worldwide (1,2)
In the epithelium of the small intestine, fructose is transported by the glucose transporter type 5 (GLUT5; encoded by SLC2A5) and phosphorylated to fructose-1-phosphate by ketohexokinase (3,4).
Fructose-1-phosphate accumulates in high concentrations in the cell (3,4)
The formation of fructose-1-phosphate has been linked to obesity and tumor promotion.
Fructose from food improves the survival of intestinal cells
Dietary fructose increases the length of the villi in several mouse models
The increase in the length of the villi increases the surface area of the intestine
By enlarging the intestinal surface, nutrient uptake is increased and obe…