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InsP3 is a microbiota-derived metabolite. It activates the mammalian Histone deacetylase 3 (HDAC3) to aid epithelial repair. HDAC3 acts as an epigenetic sensor of metabolites, adjusting host responses to microbial signals.
see also:
Gut microbiota & Histone deacetylase 3 (HDAC3)
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