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A randomized, multicenter, double-blind, phase IIb study assessed the safety and efficacy of Tropifexor and Cenicriviroc combination, compared with respective monotherapies.
Primary outcome measures:
Number of Participants With Adverse Events
The authors' conclusion was that the safety profile of the Tropifexor + Cenicriviroc combination was similar to that of the respective monotherapies, with no new signals. Tropifexor monotherapy showed sustained Alanine aminotransferase (ALT) (EC 2.6.1.2) and body weight decreases. No substantial incremental efficacy was observed with the Tropifexor + Cenicr…