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Background: A diet rich in colorful fruits and vegetables is effective for the prevention of various inflammation-induced cancer types. Mechanistically, this effect has been attributed to the potent antioxidant properties of flavonoid molecules. However, contrary to observations in mice, the success of flavonoids in human dietary cancer prevention trials is often dampened due to large interpersonal variation. Antioxidant activity alone does not explain this variability, suggesting there is an additional important variable that has not been accounted for. Since flavonoids have a poor bioavailability and predominantly passage into the large intestine, we hypothesize that gut microbial metabolism is essential for flavonoid bioactivity in colon cancer prevention.
Goals and Objectives: The goal of this study was t…