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The bacterial enzyme Purine nucleoside phosphorylase (PNP) in Escherichia coli (E. coli) activates fludarabine (a prodrug) within tumors by metabolizing fludarabine to fluoroadenine. Fluoroadenine is phosphorylated intracellularly to Fludarabine-ATP - an analog of ATP. Fludarabine-ATP incorporates into RNA, disrupting RNA synthesis and protein production
In contrast to human Purine nucleoside phosphorylase (PNP), E. coli Purine nucleoside phos…