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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Cholera Toxin (CT) & Dendritic cells (DCs)

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Cholera toxin (CT) binds to GM1-ganglioside receptors on all nucleated cells and acts as a potent mucosal adjuvant, affecting immune, nerve, and epithelial cells, and causing diarrhea.

Chimeric mice lacking GM1 in nonhematopoietic cells (including epithelial cells) showed an unaltered intestinal IgA response.

Chimeric mice lacking GM1-expressing hematopoietic cells, particularly conventional dendritic cells (cDCs), failed to elicit anti-OVA adaptive [immune res…

References (Sources)

Direct interaction between cholera toxin and DC is required for oral adjuvant activity
Gustafsson et al., 2013

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7/1/2026

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Cholera Toxin (CT) & Dendritic cells (DCs)

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