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In recent years, the methodological tools at researchers' disposal have seen significant advancements, allowing for a deeper understanding of the mechanisms by which the microbiome influences host phenotypes. Traditionally, studies relied on 16S rRNA analysis, which provided only a basic genus-level overview of the bacterial and archaeal microbiome's composition. However, there has been a shift towards metagenomic approaches, which offer a more thorough sequencing of the available genetic material, providing a more detailed and comprehensive insight.
Metagenomics is delivering vast amounts of sequence data concerning the organismal and genetic content of [gut microbial communities](brain://zRmUK0J9tkaKbN1o40IrBQ/GutMi…