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Background:
Recurrent FMT & Clostridioides difficile infection IN IBD Patients is a clinical challenge. Fecal microbiota transplantation (FMT) has emerged as a recurrent CDI therapy. Anecdotal concerns exist regarding the worsening of IBD activity; however, prospective data among IBD patients are limited.
Methods:
Secondary analysis was performed from an open-label, prospective, multicenter cohort study among IBD patients with 2 or more CDI episodes. Participants underwent a single FMT by colonoscopy (250 mL, healthy universal donor). Secondary IBD-related outcomes included rate of de novo IBD flares, worsening IBD, and IBD improvement—all based on Mayo or Harvey-Bradshaw index (HBI) scores. In addition, stool samples were collected for microbiome and targeted metabolomic profiling.
Results:
Fifty patients…