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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

AuthorsReferences (Sources)

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Prebiotics & Type 2 Diabetes (T2D)

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Recent research, including several randomized clinical trials and meta-analyses, indicates that the strongest “prebiotics-only” signal appears to be for HbA1c and some metabolic/inflammatory biomarkers in individuals with type 2 diabetes (T2D). However, it is important to note that these improvements are generally modest in effect size. Small studies, different types of prebiotics, dosages, durations, and comparison designs limit the certainty of the conclusions (1, 2, 3, 4).

Systematic reviews and meta-analyses

Review1
A systematic review and meta-analysis (2), identified by the code CRD42022352060, examined the effects of prebiotic supplementation on [gut microbiota](brain://ITew4f3yG0-qxfs…

References (Sources)

Effects of a diverse prebiotic fibre supplement on HbA1c, insulin sensitivity and inflammatory biomarkers in pre-diabetes: a pilot placebo-controlled randomised clinical trial
Hall et al. 2024 Br J Nutr 132(1): 68-76
Effects of Prebiotic and Synbiotic Supplementation on Glycaemia and Lipid Profile in Type 2 Diabetes: A Meta-Analysis of Randomized Controlled Trials
Mahboobi et al. 2018 Adv Pharm Bull 8(4): 565-574
Review
Oligofructose-enriched inulin improves some inﬂammatory markers and metabolic endotoxemia in women with type 2 diabetes mellitus: a randomized controlled clinical trial.
Dehghan et al. 2014 Nutrition 30: 418–423
Prebiotic effect of inulin-type fructans on faecal microbiota and short-chain fatty acids in type 2 diabetes: A randomised controlled trial
Birkeland et al. 2020 Eur J Nutr 59: 3325-3338
Probiotics, prebiotics, synbiotics, and FMT for glycemic control: A systematic review of clinical efficacy and mechanistic readouts in type 2 diabetes and related dysglycemia
Shalbaf et al. 2025 Metabol Open 28: 100419
Review
The effect of microbiome-modulating probiotics, prebiotics and synbiotics on glucose homeostasis in type 2 diabetes: A systematic review, meta-analysis, and meta-regression of clinical trials
Paul et al. 2022 Pharmacol Res 185: 106520
Meta-Analysis
Review
The effect of probiotics, prebiotics or synbiotics on metabolic outcomes in individuals with diabetes: A systematic review and meta-analysis
Bock et al. 2021 Diabetologia 64: 26-41
Meta-Analysis
Review

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