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Medical Research Finder

meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

Escherichia coli Nissle 1917 / E. coli Nissle 1917 (EcN) & Toll-like receptor 5 (TLR-5)

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Some studies revealed that the K5 capsule of Escherichia coli Nissle 1917 / E. coli Nissle 1917 (EcN) stimulates Toll-like receptor 5 (TLR-5) in gut epithelial cells and induces chemokine expression via the mitogen-activated protein kinase pathway
Hafez et al. 2010 Infect Immun. 78: 2153-62
Nzakizwanayo et al. 2015 PLoS ONE 10: e0120430

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Disruption of Escherichia coli Nissle 1917 K5 capsule biosynthesis, through loss of distinct kfi genes, modulates interaction with intestinal epithelial cells and impact on cell health
Nzakizwanayo et al. 2015 PLoS ONE 10: e0120430
The K5 capsule of Escherichia coli strain Nissle 1917 is important in stimulating expression of Toll-like receptor 5, CD14, MyD88, and TRIF together with the induction of interleukin-8 expression via the mitogen-activated protein kinase pathway in epithelial cells
Hafez et al. 2010 Infect Immun. 78: 2153-62

7/1/2026