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Tumor-associated Sialyl-Tn (STn) / Neu5Acα2-6GalNAc-O-Ser/Thr is linked to a poor prognosis and resistance to chemotherapy in breast carcinoma. It also inhibits DC maturation, causes DC apoptosis, and reduces NK activity.
see also:
Breast Cancer / Mammacarcinoma & ST6Gal 1 Sialyltransferase (ST6Gal-I)
Breast Cancer / Mammacarcinoma & Sialyltransferases
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