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Human MAIT cells require exogenous iron transported via the transferrin transporter CD71 to ensure optimal metabolic activity in MAIT cells, including ATP production. MAIT cells increase their expression of CD71 upon activation. In silico analyses of the MAIT cell proteome show increased iron content upon activation. MAIT cells store and use iron.
Iron deficiency by chelating environmental iron or blocking CD71 on MAIT cells results in impaired cytokine production and proliferation. Overall, these data underscore the importance of a CD71-iron axis for the metabolism and functionality of human MAIT cells.
see also:
[Microbials / Microorganisms & Mucosal-associated invariant T (MAIT) cells](brain://Vlo5lV3n-kaA1dhBABLwfw/Microbi…