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Janus kinase (JAK) and signal transducer activator of transcription (STAT) play a unique role in various disease states. Consequently, JAK inhibitors are important as therapeutics. They are being tested or used in myeloproliferative neoplasms, rheumatoid arthritis, inflammatory bowel disease, and several immune-related dermatological diseases
JAK inhibitors are approved against rheumatism, chronic IBD, myeloproliferative neoplasias, and psoriasis.
see also:
[Janus fa…