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Phosphoinositide 3-kinase (PI3K) inhibitors are a targeted therapy class in breast cancer, mainly relevant for hormone receptor-positive, HER2-negative disease with a PIK3CA mutation, where alpelisib + fulvestrant is the key established example in routine care. In breast cancer overall, the main clinical value is not the whole class in every subtype, but biomarker-selected use after endocrine therapy progression.
see also:
[Breast Cancer / Mammacarcinoma (PIK3CA m) & Drugs/Treatments](brain://rjN2scLKoUSBFsPHv8gMvA/BreastCancerMammacarcinomaPik3caMDrugsT…