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The progressive degeneration of neurons and aggravation of dopaminergic neurons in the substantia nigra pars compacta results in the loss of dopamine in the brain of Parkinson’s disease (PD) patients.
Significant therapeutic targets: chaperones, protein Abelson, glucocerebrosidase-1, calcium, neuromelanin, the ubiquitin-proteasome system, neuroinflammation, mitochondrial dysfunction, kynurenine pathway (KP).
The neurotoxic quinolinic acid (QUIN), N-methyl-D-aspartate (NMDA) receptor agonist, and neuroprotective kynurenic acid (KYNA) antagonizing QUIN actions primarily justify the Janus-faced role of KP in PD. …