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Preclinical findings:
Gut microbiota-derived proteins, specifically two polypeptides, RORDEP1 and RORDEP2, synthesized by Ruminococcus torques, are inversely related to adiposity in humans. These peptides, when administered, improved glucose tolerance, increased bone density, and reduced fat mass in mice.
Recombinant RORDEP1 affected hormone levels and enhanced insulin-mediated processes in rats, suggesting its potential for preventing and treating [metabolic disorders](brain://gaettDKt71SDbucTVdunyA/MetabolicDiseasesMetabolicDiso…