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Serine/threonine-protein kinase ATR inhibitors are a class of drugs that target the ATR (ataxia telangiectasia and Rad3-related) kinase. ATR plays a crucial role in the DNA damage response (DDR) pathway, making these inhibitors a significant focus in cancer research. Their potential to enhance the effectiveness of existing cancer treatments and target tumor cells with specific vulnerabilities has garnered considerable attention.
Serine/threonine-protein kinase ATR inhibitors have demonstrated anti-tumor activity both as monotherapies and in combination with other treatments such as:
They are particularly effective in tumors with high le…