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It has been shown that genetic predispositions play a significant role in imbalanced energy metabolism (for example, obesity). Epigenetic modifications ( DNA methylation, histone modifications, non-coding RNAs) affect how DNA is transcribed without changing its sequence. In particular, these epigenetic changes are reversible.
Epigenetics refers to heritable mechanisms responsible for regulating gene expression, including genes involved in the hypoxia response, without altering the sequence of DNA bases. The cellular microenvironment, such as O2 levels, strongly influences these mechanisms. The balance and interac…