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The gut lumen contains high levels of nucleobase uridine. Pathogens use transport proteins (NupC) for the uptake of uridine. Within the pathobiont, it is metabolized (NH) into uracil and ribose. Intracellular ribose sustains quorum-sensing and virulence-factor expression, both required to induce host cell damage (1). Do enterocytes detect bacteria-generated uracil, it acts a…