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The Serum glucocorticoid kinase 1 (SGK1) inhibitor SI113 shows antineoplastic effects with low toxicity in models. It can cross the blood-brain barrier, suggesting potential use in psychiatric and neurological diseases. It disrupts the epithelial-to-mesenchymal transition and alters cytoskeletal organization in human cancer cells.
The SGK1 Inhibitor SI113, in a preclinical model of ovarian cancer, counteracts the development of paclitaxel resistance and restores drug sensitivity.
SI113 works in conjunction with mitotic spindle poisons to halt the growth of human [glioblastoma multifor…