Clonal hematopoiesis

Clonal hematopoiesis of indeterminate potential is a common aging-related phenomenon in which Human pluripotent stem cells (hPSCs) or other early blood cell progenitors contribute to the formation of a genetically distinct subpopulation of blood cells
Steensma et al. 2015 Blood 126(1): 9-16
Jan et al. 2017 Seminars in Hematology 54 (1): 43-50
Sperling et al. 2017 Nat Rev Cancer 17(1): 5-19

Our understanding of how clonal hematopoiesis relates to diverse health conditions has vastly expanded over the past years, impacting many specialties beyond cancer medicine. Given that clonal hematopoiesis can act as a precursor to overt disease in various settings, the promise of early intervention has garnered si…