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Distinguishing human CD4+ CD25++ FOXP3 low nTreg / tTreg from CD4+ CD25+ FOXP3 high Treg (peripherally induced) is challenging because there are no specific markers.
However, GPA33 is a reliable marker for identifying human CD4+ CD25++ FOXP3 low nTreg / tTreg. This discovery offers a strategic method for isolating these cells, which enhances the safety and efficacy of adoptive cell therapy.
In the later stages of CD4+ CD25++ FOXP3 low nTreg / tTreg development, GPA33 is acquired, but it is absent in [Transforming growth factor beta (TGF-beta)](brain://0H…