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NCT02562014
In this randomized, clinical basic science trial, it was found that acute increases in colonic short-chain fatty acids (SCFA) do not influence the responses of GLP-1 or PYY in lean (LN) or overweight/obese (OWO) subjects. However, there may be a reduction in ghrelin levels. These findings do not support the hypothesis that SCFA acutely stimulate the secretion of PYY and GLP-1. Nonetheless, it is possible that a longer period of adaptation to increased …