B cells & Gut microbiota

Colonization by the microbiota significantly stimulates B cells and induces immunoglobulin production. Mammals colonized with various taxa develop highly complex and individualized immunoglobulin repertoires (IgA and IgG Repertoire).
Li et al. 2020n

The IgA repertoire, which predominantly targets cell-surface antigens, did not expand after baxterial dose escalation.
Increased systemic exposure broadened the IgG repertoire to include both microbial cytoplasmic and cell-surface antigens.
Li et al. 2020n

Microbial exposures induced characteristic immunoglobulin heavy-chain repertoires in B cells, primarily at the memory and plasma cell stages. The responses varied based on the type of exposure:

• Systemic Exposure: Sequential systemic exposure to differe…