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The vitamin A metabolite retinol is critical for B and T cell development and homing to the gut.
Intestinal myeloid cells such as dendritic cells and macrophages take up retinol and process it into retinoic acid (RA), which in turn initiates RA-dependent gene expression programs in lymphocytes.
LDL receptor-related protein 1 (LRP1) is a myeloid cell surface receptor for retinol.
LRP1 binds retinol chaperoned by serum amyloid A (SAA) proteins
SAA–retinol complexes are then endocytosed and metabolized by myeloid cells
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