Medical Research Finder

Start
Features
Free trial / FAQ

Researchers
Physicians
Pharmacists
Ecotrophologists
Product Managers
in Health Industries

Loading…

© 2026 meRfi®

Medical Research Finder

Legal Notice
Privacy
Terms of Use

meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

AuthorsReferences (Sources)

meRfi® AI Chat

Crohn's disease (CD) & Paneth Cells

Welcome to meRfi Microbiome!

Please register to continue your trial period!

meRfi Microbiome provides you with up-to-date, evidence-based insights on the gut microbiota and related health topics.

Access our ever-expanding digital library and get personalized answers through our interactive AI chat platform.

Start your free trial and transform your understanding of the gut microbiota today!

Register for a free trial

Navigation

Contents

Investigation of atg16l1 gene, an autophagy gene linked to Crohn’s disease susceptibility, has supported a link between Paneth cells and intestinal inflammation. Atg16l1-mutant mice and patients with Crohn’s disease who are homozygous for the ATG16L1 T300A risk allele display reductions in the number of Paneth cells with intact granules
Cadwell et al. 2008 Nature 456: 259-263

Loss of Paneth cells and their antimicrobial granules compromises the intestinal epithelial barrier and is associated with Crohn’s disease
Cadwell et al. 2008 Nature 456: 259-263
Bevins et al. 2009 Gut 58: 882-883
Adolph et al. 2013 Nature 503: 272-27…

References (Sources)

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells
Cadwell et al. 2008 Nature 456: 259-263
Decreased Paneth cell defensin expression in ileal Crohn's disease is independent of inflammation, but linked to the NOD2 1007fs genotype
Bevins et al. 2009 Gut 58: 882-883
Genetic variants synthesize to produce paneth cell phenotypes that define subtypes of Crohn's disease
VanDussen et al. 2014 Gastroenterology 146: 200-209
Irgm1-deficient mice exhibit Paneth cell abnormalities and increased susceptibility to acute intestinal inflammation
Liu et al. 2013 Am. J. Physiol. 305: G573-G584
Paneth cells as a site of origin for intestinal inflammation
Adolph et al. 2013 Nature 503: 272-276
Paneth cells secrete lysozyme via secretory autophagy during bacterial infection of the intestine
Bel et al. 2017 Science 357: 1047-1052
Spatial and temporal stability of paneth cell phenotypes in Crohn's disease: implications for prognostic cellular biomarker development
Liu et al. 2014 Inflamm. Bowel Dis. 20: 646-651

AI Chat

7/1/2026

Chat with our artificial intelligence: